Progestin-Only Injectables

What Are Progestin-Only Injectables?
Inject prog

  • The injectable contraceptives depot medroxyprogesterone acetate (DMPA) and norethisterone enanthate (NET-EN) each contain a progestin like the natural hormone progesterone in a woman’s body.
  • Do not contain estrogen, and so can be used throughout breastfeeding and by women who cannot use methods with estrogen.
  • DMPA, the most widely used progestin-only injectable, is also known as “the shot,” “the jab,” the injection, Depo, Depo-Provera, Megestron, and Petogen.
  • NET-EN is also known as norethindrone enanthate, Noristerat, and Syngestal.
  • Given by injection into the muscle (intramuscular injection). The hormone is then released slowly into the bloodstream. A different formulation of DMPA can be injected just under the skin (subcutaneous injection).
  • Work primarily by preventing the release of eggs from the ovaries (ovulation).


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